Cheap American Airlines flights Pensacola (PNS) to San Diego (SAN)

Set the "Price (lowest to highest)" filter on Expedia to search for cheap American Airlines round-trip flights from PNS to SAN. Affordable one-way options are available too.*

*These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to San Diego are generally cheaper in the low-season months of January and November. Whether you're after a one-way or round-trip ticket, you could score a better deal then.

To figure out if there's a direct trip from PNS to SAN with American Airlines or any other airlines, check the "Nonstop" box when searching for flights.

Take an American Airlines flight from Pensacola Intl. Airport (PNS) to San Diego, and you'll likely touch down at San Diego Intl. Airport (SAN). This is the airline's main hub in this destination.

Depending on the type of ticket you purchased, a fee is typically charged if you cancel or change your flight more than 24 hours after confirmation. To secure flexible plane tickets, select our "No cancel fee" or "Changes included" filter when looking for flights. To learn more about modifying or canceling your reservation, go to "Trips," select your flight and click on "Manage Booking."