Cheap American Airlines flights Houston (HOU) to San Diego (SAN)

Scoring cheap one-way American Airlines flights from HOU to SAN on Expedia couldn't be simpler — just filter by "Price (lowest to highest)." Or check out our budget-friendly round-trip fares for your next exciting getaway.*

*These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the most affordable months to jet away to San Diego with American Airlines. You could also find fantastic deals on return and one-way tickets in November.

Use our "Nonstop" filter when looking for direct American Airlines flights from HOU to SAN. You'll also be able to compare other airlines offering the same direct trip.

San Diego Intl. Airport (SAN) is the main San Diego hub for American Airlines flights from William P. Hobby Airport (HOU).

Changes are generally free within 24 hours of making a booking, but your airline may add a charge after that. For further details about altering your reservation, check out your "Trips," select your flight and click on "Manage Booking." If you'd like the flexibility to adjust your plans without additional charges, tick the "No cancel fee" or "Changes included" filter when organizing your next break.