Cheap American Airlines flights Tampa (TPA) to San Diego (SAN)

Finding cheap one-way American Airlines flights from TPA to SAN on Expedia is easy — just filter by "Price (lowest to highest)." Alternatively, check out our affordable return fares for your next adventure.*

*These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for return or one-way flights to San Diego in January or November. You could find a cheap fare with American Airlines during these off-peak months.

To find out if there's a direct route from TPA to SAN with American Airlines or other carriers, use our "Nonstop" filter when looking for tickets.

Catch an American Airlines flight from Tampa Intl. Airport (TPA) to San Diego, and you'll most likely come in to San Diego Intl. Airport (SAN). This is the airline's primary hub in this city.

Depending on your ticket type, a fee generally applies if you cancel or change your booking more than 24 hours after it's been confirmed. To find tickets with more flexibility, select our "Changes included" and "No cancel fee" boxes when you look for flights. For more information on canceling or changing your reservation, head to "Trips," select your flight and click on "Manage Booking."