Cheap American Airlines flights Buffalo (BUF) to San Diego (SAN)

Landing cheap one-way American Airlines flights from BUF to SAN on Expedia is easy — just filter by "Price (lowest to highest)." Alternatively, check out our budget-friendly round-trip fares for your next break.*

*These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the cheapest months to jet away to San Diego with American Airlines. You could also find great prices on one-way and return fares in November.

To figure out if there's a direct journey from BUF to SAN with American Airlines or another carrier, check the "Nonstop" box when browsing for flights.

Take an American Airlines flight from Buffalo Niagara Intl. Airport (BUF) to San Diego, and you'll likely arrive at San Diego Intl. Airport (SAN). This is the airline's main hub in this destination.

Typically, you can reschedule or cancel your flight, although there may be a charge if you booked more than 24 hours ago. Need to keep your options open? Apply the "Changes included" and "No cancel fee" filters to find flights that won't charge extra if you need to adjust your plans. To modify your booking, head to "Trips," select your flight and click on "Manage Booking" for more details.